Title: QTL affecting body weight in a candidate region of cattle chromosome 5

Author(s):  Machado MBB, Alencar MM, Pereira AP, Oliveira HN, Casas E, Coutinho LL , Regitano LCA

Source:  GENETICS AND MOLECULAR BIOLOGY 26 (3): 259-265 SEP 2003

Document Type:  Article

Language:  English

Abstract:  The objective of this work was to identify QTLs for liveweight in a candidate region of bovine chromosome 5. Half-sib families from two lines, one traditional and the other new, of Canchim beef cattle (5/8 Charolais + 3/8 Zebu) were genotyped for four microsatellite markers, including the microsatellite in the IGF-1 (insulin-like growth factor-1) promoter region. Significant differences in allele distribution between the two lines were found for three markers. Interval mapping analyses in this region indicated the presence of a QTL controlling birth weight (p < 0.05) and of a QTL influencing breeding value for yearling weight (p < 0.01) in the newer line of the breed. The previously identified interaction between the IGF-1 genotype and genetic group strengthens the hypothesis of a linked QTL rather than an IGF-1 effect on growth traits in the Canchim cattle. Author Keywords:  QTL; growth traits; microsatellite; bovine

KeyWords Plus:  QUANTITATIVE TRAIT LOCI; GENETIC-LINKAGE MAP; BOVINE GENOME; TWINNING RATE; GROWTH; POLYMORPHISMS; POPULATIONS; MICE

Addresses:  Regitano LCA (reprint author), Embrapa Pecuaria Sudeste, Caixa Postal 339, Sao Carlos, SP BR-13560970 Brazil
Embrapa Pecuaria Sudeste, Sao Carlos, SP BR-13560970 Brazil
Univ Fed Sao Carlos, Dept Genet & Evolucao, Sao Carlos, SP BR-13560 Brazil
Univ Estadual Paulista Julio Mesquita Filho, Dept Reprod & Nutr Anim, Botucatu, SP Brazil
USDA ARS, Meat Anim Res Ctr, Clay Ctr, NE 68933 USA
Univ Sao Paulo, Dept Anim Prod, Piracicaba, SP Brazil Publisher:  SOC BRASIL GENETICA, RUA CAP ADELMIO NORBET DA SILVA, 736, ALTO DA BOA VISTA, 14025-670 RIBEIRAO PRET, BRAZIL

Subject Category:  BIOCHEMISTRY & MOLECULAR BIOLOGY; GENETICS & HEREDITY IDS Number:  741GR

ISSN:  1415-4757