Title: ALPHA-2-ADRENERGIC RECEPTOR ACTIVITY IN PORCINE ADIPOCYTES IS ANDROGEN AND AGE CELL-SIZE DEPENDENT

Author(s): COUTINHO LL , BERGEN WG, ROMSOS DR, MERKEL RA

Source:  COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-PHYSIOLOGY 105 (2): 333-339 JUN 1993

Document Type:  Article

Language:  English

Abstract:  1. Using epinephrine plus propranolol we demonstrated alpha-2 adrenergic receptor (alpha2AR) activity (49% inhibition of theophylline stimulated lipolysis) in adipocytes of adult intact male pigs (61 kg body wt and 97 mum adipocyte diameter).

2. Dose titration with an alpha2AR antagonist (yohimbine) confirmed alpha2AR associated activity.

3. No alpha2AR activity was observed in younger male or castrated male pigs.

4. The inhibitory action on lipolysis via the alpha2AR in pigs is dependent on androgen status and adipocyte size or age.

KeyWords Plus:  WHITE FAT-CELLS; HAMSTER ADIPOCYTES; ADIPOSE-TISSUE; LIPOLYSIS; ADRENOCEPTORS; RESPONSES; OBESITY

Addresses:  MICHIGAN STATE UNIV, DEPT ANIM SCI, E LANSING, MI 48824 USA
MICHIGAN STATE UNIV, DEPT FOOD SCI & HUMAN NUTR, E LANSING, MI 48824 USA

Publisher:  PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB

Subject Category:  BIOCHEMISTRY & MOLECULAR BIOLOGY; PHYSIOLOGY; ZOOLOGY

IDS Number:  LF711

ISSN:  0300-9629